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Inspection Decision Scenarios Regulatory Impact Decisions

FDA Inspection Decision Scenario

Who Authorized the Cleaning Validation Acceptance?

21 CFR 211.67FDA Cleaning Validation Guidance

What FDA investigators are actually asking

FDA Investigator Question

"Who made the determination that your cleaning validation data supported the claimed cleaning effectiveness?"

Inspector's Line of Inquiry

When investigators ask this question, they typically follow with:

  • Who reviewed the swab and rinse data before the cleaning validation was accepted?
  • What worst-case conditions were evaluated before the acceptance determination was made?
  • What acceptance criteria were applied and who established them?
  • What results would have required the cleaning process to be revalidated?
  • When was the cleaning validation formally authorized, and who is named as the decision owner?

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The authorization gap this scenario reveals

The investigator is reviewing cleaning validation records. Swab and rinse data are present. Acceptance criteria are met. The investigator asks who authorized the acceptance.

Authorization Gap

The cleaning validation record documents test results against acceptance criteria. It does not document who evaluated the totality of cleaning data and made the formal authorization that the process was validated. This is the authorization gap: the decision was made, but it was never documented as an authorization event — with a named decision owner, the evidence reviewed, the regulatory standard applied, and a timestamped record of when the authorization occurred.

What evidence the investigator expects

Organizations operating with authorization infrastructure produce this record at the moment the decision is made.

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These gaps are not documentation failures. They are authorization failures. The Authorization Assessment maps exactly where your decision trail is missing these elements.

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Authorization Assessment

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The Authorization Assessment identifies where your compliance decisions are undocumented as authorization events — the exact gap inspectors expose in scenarios like this one.

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Inspection Case Files document the authorization gap in detail — showing exactly what a Decision Defense Record resolves and what inspectors expect to see.

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