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Inspection Decision Scenarios Investigation Closure Decisions

FDA Inspection Decision Scenario

Who Authorized This CAPA Closure?

21 CFR 820.100

What FDA investigators are actually asking

FDA Investigator Question

"Who made the determination that this CAPA was effective, and what evidence supported that conclusion?"

Inspector's Line of Inquiry

When investigators ask this question, they typically follow with:

  • Who reviewed the effectiveness check results before the closure decision was made?
  • What data was considered when determining the corrective action was sufficient?
  • What regulatory standard was applied to the effectiveness determination?
  • What would have prevented the CAPA from being closed?
  • When was the closure authorization made, and who is named as the decision owner?

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The authorization gap this scenario reveals

The investigator pulls a closed CAPA from eighteen months ago. The effectiveness check is marked complete. The investigator asks who authorized the closure.

Authorization Gap

The CAPA record shows corrective action steps were completed. It does not show who evaluated the effectiveness evidence and made the formal closure authorization — or that anyone did. This is the authorization gap: the decision was made, but it was never documented as an authorization event — with a named decision owner, the evidence reviewed, the regulatory standard applied, and a timestamped record of when the authorization occurred.

What evidence the investigator expects

Organizations operating with authorization infrastructure produce this record at the moment the decision is made.

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Inspection Case File

See exactly what this authorization gap looks like — and what closes it.

The case file reconstructs this scenario in full: the investigator's question, the record that existed, the authorization evidence that was missing, and the Decision Defense Record that resolves it.

Inspection Case File

Close this authorization gap
before inspection.

The case file documents this exact scenario — the investigator's question, the missing authorization trail, and the Decision Defense Record that produces the evidence inspectors expect.

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